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Home : A : Acetaminophen : Acetaminophen and Amobarbital Sodium

Effects and Recommendation :
Resulting In: liver damage Amobarbital Sodium may reduce the pharmacologic effects of Acetaminophen. Chronic use of Amobarbital Sodium may increase risk of Acetaminophen induced liver toxicity.
No monitoring or adjustment appear to be necessary at regular doses.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Douidar SM, et al. J Pharmacol Exp Ther. 1987: 240:578.
Publication : J Pharmacol Exp Ther by
> Douidar SM, et al - - 240:578
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Pirotte JH. Ann Intern Med. 1984: 101:403.
Publication : Ann Intern Med by
> Pirotte JH - - 101:403
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Prescott LF, et al. Br J Clin Pharmacol. 1981: 12:149.
Publication : Br J Clin Pharmacol by
> Prescott LF, et al - - 12:149