Acetaminophen and Sulfinpyrazone

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Home : A : Acetaminophen : Acetaminophen and Sulfinpyrazone

Effects and Recommendation :
Resulting In: liver damage Sulfinpyrazone may increase the risk of liver toxicity from Acetaminophen. Sulfinpyrazone may reduce the pharmacologic effects of Acetaminophen.
No monitoring or adjustment appear to be necessary at regular doses.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Abernethy DR, et al. J Pharmacol Exp Ther. 1985: 234:345.
Publication : J Pharmacol Exp Ther by
> Abernethy DR, et al - - 234:345
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Miners JO, et al. Clin Pharmacol Ther. 1984: 35:480.
Publication : Clin Pharmacol Ther by
> Miners JO, et al - - 35:480