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Home : A : Acetazolamide : Acetazolamide and Topiramate
Effects and Recommendation :
The combination may increase the risk of renal stone formation.
Combination should be avoided but if not, encourage an increase in water intake.
Severity of the interaction : 3/6
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Information on this interaction is found in the following publications :
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Dodgson SJ, Shank RP, Maryanoff BE, et al. "Topiramate as an inhibitor of carbonic anhydrase isoenzymes." Epilepsia. 2000;41 Suppl 1: S35-9.
Publication : Epilepsia by
> Dodgson SJ, Shank RP, Maryanoff BE, et al - Topiramate as an inhibitor of carbonic anhydrase i - S35-9
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Takhar J, Manchanda R, et al. "Nephrolithiasis on topiramate therapy." Can J Psychiatry. 2000 Jun;45: 491-3.
Publication : Can J Psychiatry by
> Takhar J, Manchanda R, et al - Nephrolithiasis on topiramate therapy - 491-3
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