Rifampin and Dapsone

Effects and Recommendation :
Rifampin may reduce the pharmacologic effects of Dapsone.
Monitor for patient response to DAPSONE and increase dosage as needed. Consider using as alternative to RIFAMPIN.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
----------
Gelber RH, et al. J Trop Med Hyg. 1975: 24:963.
Publication : J Trop Med Hyg by
> Gelber RH, et al - - 24:963
----------
Horowitz HW, et al. Lancet. 1992: 339:747.
Publication : Lancet by
> Horowitz HW, et al - - 339:747
----------
Krishna DR, et al. Drug Develop Indust Pharm. 1986: 12:443.
Publication : Drug Develop Indust Pharm by
> Krishna DR, et al - - 12:443
----------
Peters JH, et al. Fed Proc. 1977: 36:996. [Abstract].
Publication : Fed Proc by
> Peters JH, et al - - 36:996. [Abstract]

Home : D : Dapsone : Rifampin and Dapsone