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Home : F : Felbamate : Felbamate and Gabapentin

Effects and Recommendation :
Gabapentin may increase the serum levels and pharmacological and adverse effects of Felbamate. Gabapentin may reduce the clearance, prolong the half-life and increase the serum levels of Felbamate.
Monitor patient response to FELBAMATE when starting or stopping GABAPENTIN. This combination may be beneficial in epileptic patients.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Hussein G, et al. "Gabapentin interaction with felbamate." Neurology. 1996 Oct;47: 1106.
Publication : Neurology by
> Hussein G, et al - Gabapentin interaction with felbamate - 1106