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Home : F : Fluoxetine : Metoprolol and Fluoxetine

Effects and Recommendation :
Resulting In: Bradycardia Concomitant use of Fluoxetine and Metoprolol can potentiate some adverse effects.
Monitor cardiac function when taking ceratin BETA BLOCKERS and SSRI. Sotalol (Betapace) may be a safer alternative.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Walley T, Pirmohamed M, Proudlove C, Maxwell D,. "Interaction of metoprolol and fluoxetine." Lancet. 1993 Apr 10: 341:967-8.
Publication : Lancet by
> Walley T, Pirmohamed M, Proudlove C, Maxwell D, - Interaction of metoprolol and fluoxetine - 341:967-8