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Home : G : Gemfibrozil : Simvastatin and Gemfibrozil
Effects and Recommendation :
Resulting In: Rhabdomyolysis Concomitant use of Simvastatin and Gemfibrozil can potentiate some adverse effects.
Avoid this drug combination if possible. This drug combination, however, may be beneficial in patients with severe hyperlipidemias. Monitor patients for signs of muscle pain and weakness. The recommended Max dose in these cases is 10mg/day.
Severity of the interaction : 5/6
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Information on this interaction is found in the following publications :
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Duell PB, et al. Am J Cardiol. 1998: 81:368.
Publication : Am J Cardiol by
> Duell PB, et al - - 81:368
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East C, et al. N Engl J Med. 1988: 318:47.
Publication : N Engl J Med by
> East C, et al - - 318:47
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Glueck CJ, et al. Am J Cardiol. 1992: 70:1.
Publication : Am J Cardiol by
> Glueck CJ, et al - - 70:1
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Marais GE, et al. Ann Intern Med. 1990: 112:228.
Publication : Ann Intern Med by
> Marais GE, et al - - 112:228
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Pasternak RC, et al. Ann Intern Med. 1996: 125:529.
Publication : Ann Intern Med by
> Pasternak RC, et al - - 125:529
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Pierce LR, et al. JAMA. 1990: 264:71.
Publication : JAMA by
> Pierce LR, et al - - 264:71
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Product Information. Simvastatin (Zocor). Merck, June 2002.
Publication : Simvastatin (Zocor) by Product Information
> Product Information - -
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Tal A, et al. South Med J. 1997: 90:546.
Publication : South Med J by
> Tal A, et al - - 90:546
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Van Puijenbroek EP, et al. J Intern Med. 1996: 240:403.
Publication : J Intern Med by
> Van Puijenbroek EP, et al - - 240:403
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Wirebaugh SR, et al. Pharmacotherapy. 1992: 12:445.
Publication : Pharmacotherapy by
> Wirebaugh SR, et al - - 12:445
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