Imipramine HCl and Ethinyl Estradiol/Levonorgestrel

Effects and Recommendation :
Ethinyl Estradiol/Levonorgestrel may increase serum levels of Imipramine HCl.
Monitor TCA level and patient response. Adjust TCA dose as needed.
Severity of the interaction : 1/6

Information on this interaction is found in the following publications :
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Abernethy DR, et al. Clin Pharmacol Ther. 1984: 35:792.
Publication : Clin Pharmacol Ther by
> Abernethy DR, et al - - 35:792
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Edelbroek PM, et al. Clin Chim Acta. 1987: 165:177.
Publication : Clin Chim Acta by
> Edelbroek PM, et al - - 165:177
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Gringas M, et al. J Int Med Res. 1980: 8(Suppl 3):76.
Publication : J Int Med Res by
> Gringas M, et al - - 8(Suppl 3):76
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John VA, et al. J Int Med Res. 1980: 8(Suppl 3): 88.
Publication : J Int Med Res by
> John VA, et al - - 8(Suppl 3): 88

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