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Home : I : Imipramine HCl : Phenytoin Sodium, Prompt and Imipramine HCl
Effects and Recommendation :
Imipramine HCl may increase the serum levels and pharmacological and adverse effects of Phenytoin.
Monitor PHENYTOIN level and watch for signs of toxicity. Adjust PHENYTOIN dosage as needed.
Severity of the interaction : 3/6
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Information on this interaction is found in the following publications :
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Houghton GW, et al. Int J Clin Pharmacol. 1975: 12:210.
Publication : Int J Clin Pharmacol by
> Houghton GW, et al - - 12:210
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Perucca E, et al. Br J Clin Pharmacol. 1977: 4:485.
Publication : Br J Clin Pharmacol by
> Perucca E, et al - - 4:485
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Pond SM, et al. Clin Pharmacol Ther. 1975: 18:191.
Publication : Clin Pharmacol Ther by
> Pond SM, et al - - 18:191
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