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Effects and Recommendation :
Indomethacin may increase serum levels of Digoxin in premature infants.
Caution is warranted in preterm infants with reduced renal function. Until urine output and serum DIGOXIN levels are assessed, consider decreasing the DIGOXIN dose by 50% when INDOMETHACIN is added to DIGOXIN therapy in preterm infants.
Severity of the interaction : 3/6
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Information on this interaction is found in the following publications :
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Finch MB, et al. Br J Clin Pharmacol. 1984: 17:353.
Publication : Br J Clin Pharmacol by
> Finch MB, et al - - 17:353
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Jorgensen HS, et al. Br J Clin Pharmacol. 1991: 31:108.
Publication : Br J Clin Pharmacol by
> Jorgensen HS, et al - - 31:108
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Koren G, et al. Pediat Pharmacol. 1984: 4:25.
Publication : Pediat Pharmacol by
> Koren G, et al - - 4:25
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Mayes LC, et al. Pediatr Res. 1980: 14:469.
Publication : Pediatr Res by
> Mayes LC, et al - - 14:469
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Schimmel MS, et al. Clin Pediatr. 1980: 19:768.
Publication : Clin Pediatr by
> Schimmel MS, et al - - 19:768
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