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Home : K : Kanamycin : Polymyxin B Sulfate and Kanamycin

Effects and Recommendation :
Resulting In: renal dysfunction, Respiratory paralysis Coadministration of Polymyxin B Sulfate and Kanamycin may result in respiratory paralysis and renal dysfunction.
Monitor renal and respiratory function and discontinue one drug or the other if necessary.
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Koch-Weser J, et al. Ann Intern Med. 1970: 72:857.
Publication : Ann Intern Med by
> Koch-Weser J, et al - - 72:857
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Lee C, et al. Anesthesiology. 1979: 50:218.
Publication : Anesthesiology by
> Lee C, et al - - 50:218
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Lindesmith LA, et al. Ann Intern Med. 1968: 68:318.
Publication : Ann Intern Med by
> Lindesmith LA, et al - - 68:318