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Home : K : Kaolin : Kaolin and Diflunisal
Effects and Recommendation :
Kaolin may reduce the serum levels and pharmacological effects of Diflunisal.
Try to separate administration time of DIFLUNISAL and ALUMINUM SALTS by 2 to 3 hours. Occasional use of ALUMINUM SALTS do not require any DIFLUNISAL dosage adjustment; however, regular use may necessitate an increased in DIFLUNISAL dosage.
Severity of the interaction : 3/6
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Information on this interaction is found in the following publications :
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D'Arcy PF, McElnay JC. "Drug-antacid interactions:assessment of clinical importance.." Drug Intell Clin Pharm. 1987 Jul-Aug: 21(7-8):607-17 Revie.
Publication : Drug Intell Clin Pharm by
> D'Arcy PF, McElnay JC - Drug-antacid interactions:assessment of clinical i - 21(7-8):607-17 Revie
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Holmes GI, et al. Clin Pharmacol Ther. 1979: 25:229.
Publication : Clin Pharmacol Ther by
> Holmes GI, et al - - 25:229
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Tobert JA, et al. Clin Pharmacol Ther. 1981: 30:385.
Publication : Clin Pharmacol Ther by
> Tobert JA, et al - - 30:385
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Verbeeck R, et al. Br J Clin Pharmacol. 1979: 7:519.
Publication : Br J Clin Pharmacol by
> Verbeeck R, et al - - 7:519
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