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Home : K : Ketoconazole : Alprazolam and Ketoconazole
Effects and Recommendation :
Resulting In: CNS depression, sedation Ketoconazole can increase the serum levels of Alprazolam and increase the risk of toxicity.
Use of ALPRAZOLAM with KETOCONAZOLE is contraindicated. Use a lower dose of BENZODIAZEPINES when using FLUCONAZOLE or MICONAZOLE.
Severity of the interaction : 6/6
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Information on this interaction is found in the following publications :
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Ahonen J, et al. Eur J Clin Pharmacol. 1997: 51:415.
Publication : Eur J Clin Pharmacol by
> Ahonen J, et al - - 51:415
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Ahonen J, et al. Ther Drug Monit. 1996: 18:124.
Publication : Ther Drug Monit by
> Ahonen J, et al - - 18:124
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Backman JT, et al. Eur J Clin Pharmacol. 1998: 54:53.
Publication : Eur J Clin Pharmacol by
> Backman JT, et al - - 54:53
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Brown MW, et al. Clin Pharmacol Ther. 1985: 37:290.
Publication : Clin Pharmacol Ther by
> Brown MW, et al - - 37:290
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Greenblatt DJ, et al. Clin Pharmacol Ther. 1998: 64:237.
Publication : Clin Pharmacol Ther by
> Greenblatt DJ, et al - - 64:237
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Greenblatt DJ, et al. Lancet. 1995: 345:191.
Publication : Lancet by
> Greenblatt DJ, et al - - 345:191
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Neuvonen PJ, et al. Clin Pharmacol Ther. 1996: 60:326.
Publication : Clin Pharmacol Ther by
> Neuvonen PJ, et al - - 60:326
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Olkkola KT, et al. Anesth Analg. 1996: 82:511.
Publication : Anesth Analg by
> Olkkola KT, et al - - 82:511
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Olkkola KT, et al. Clin Pharmacol Ther. 1994: 55:481.
Publication : Clin Pharmacol Ther by
> Olkkola KT, et al - - 55:481
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Varhe A, et al. Br J Clin Pharmacol. 1996: 41:319.
Publication : Br J Clin Pharmacol by
> Varhe A, et al - - 41:319
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Varhe A, et al. Br J Clin Pharmacol. 1996: 42:465.
Publication : Br J Clin Pharmacol by
> Varhe A, et al - - 42:465
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Varhe A, et al. Clin Pharmacol Ther. 1994: 56:601.
Publication : Clin Pharmacol Ther by
> Varhe A, et al - - 56:601
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Von Moltke LL, et al. J Clin Pharmacol. 1996: 36:783.
Publication : J Clin Pharmacol by
> Von Moltke LL, et al - - 36:783
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Yasui N, et al. Psychopharmacology. 1998: 139:269.
Publication : Psychopharmacology by
> Yasui N, et al - - 139:269
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