Ethinyl Estradiol/Norethindrone Acetate and Ketoconazole

Effects and Recommendation :
Resulting In: contraceptive failure Ketoconazole can increase the estrogen serum level contained in Ethinyl Estradiol/Norethindrone Acetate possibly resulting in increased adverse reactions. Ketoconazole can reduce the effectivness of Ethinyl Estradiol
Warn women about the risk of contraceptive fialure. Conside an alternative method of birth control.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Devenport MH, et al. Br J Clin Pharmacol. 1989: 27:851.
Publication : Br J Clin Pharmacol by
> Devenport MH, et al - - 27:851
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Lazar JD, et al. Reviews Infect Dis. 1990: 12 (Suppl 3):s327.
Publication : Reviews Infect Dis by
> Lazar JD, et al - - 12 (Suppl 3):s327
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Pillans PI, et al. NZ Med J. 1993: 106:436.
Publication : NZ Med J by
> Pillans PI, et al - - 106:436
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Sinofsky FE, et al. Am J Obstet Gynecol. 1998: 178:300.
Publication : Am J Obstet Gynecol by
> Sinofsky FE, et al - - 178:300

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