Ethinyl Estradiol and Ketoconazole

Effects and Recommendation :
Ketoconazole can reduce the effectivness of Ethinyl Estradiol. Ketoconazole may increase serum levels of Ethinyl Estradiol.
Warn women about the risk of contraceptive failure. Conside an alternative method of birth control.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Devenport MH, et al. Br J Clin Pharmacol. 1989: 27:851.
Publication : Br J Clin Pharmacol by
> Devenport MH, et al - - 27:851
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Lazar JD, et al. Reviews Infect Dis. 1990: 12 (Suppl 3):s327.
Publication : Reviews Infect Dis by
> Lazar JD, et al - - 12 (Suppl 3):s327
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Pillans PI, et al. NZ Med J. 1993: 106:436.
Publication : NZ Med J by
> Pillans PI, et al - - 106:436
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Sinofsky FE, et al. Am J Obstet Gynecol. 1998: 178:300.
Publication : Am J Obstet Gynecol by
> Sinofsky FE, et al - - 178:300

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