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Home : K : Ketoconazole : Ketoconazole and Dofetilide

Effects and Recommendation :
Resulting In: Ventricular arrhythmias, Torsades de pointes Concurrent use of Ketoconazole and Dofetilide may cause life-threatening cardiac arrhythmias, including torsades de pointes. Ketoconazole is contraindicated with Dofetilide.
Contraindicated.
Severity of the interaction : 6/6

Information on this interaction is found in the following publications :
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Product Information. Dofetilide (Tikosyn). Pfizer Labs, December 1999.
Publication : Dofetilide (Tikosyn) by Product Information
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