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Home : K : Ketoconazole : Sodium Bicarbonate and Ketoconazole

Effects and Recommendation :
Sodium Bicarbonate may reduce the pharmacologic effects of Ketoconazole.
Give ANTACIDS at least 2 hours after KETOCONAZOLE.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Brass C, et al. Antimicrob Agents Chemother. 1982: 21:151.
Publication : Antimicrob Agents Chemother by
> Brass C, et al - - 21:151
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Carlson JA, et al. Am J Hosp Pharm. 1983: 40:1334.
Publication : Am J Hosp Pharm by
> Carlson JA, et al - - 40:1334
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Lelawongs P, et al. Clin Pharm. 1988: 7:228.
Publication : Clin Pharm by
> Lelawongs P, et al - - 7:228
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Thorpe JE, et al. Antimicrob Agents Chemother. 1990: 34:2032.
Publication : Antimicrob Agents Chemother by
> Thorpe JE, et al - - 34:2032
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Van Der Meer JWM, et al. J Antimicrob Chemother. 1980: 6:552.
Publication : J Antimicrob Chemother by
> Van Der Meer JWM, et al - - 6:552