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Home : K : Ketoconazole : Warfarin Sodium and Ketoconazole

Effects and Recommendation :
Ketoconazole can increase the anticoagulant effects of Warfarin Sodium.
Monitor anticoagulation factors frequently when adding an AZOLE ANTIFUNGAL to WARFARIN. Adjust dose of ANTICOAGULANT as necessary.
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Brass C, et al. Antimicrob Agents Chemother. 1982: 21:151.
Publication : Antimicrob Agents Chemother by
> Brass C, et al - - 21:151
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Colquhoun MC, et al. Lancet. 1987: 1:695.
Publication : Lancet by
> Colquhoun MC, et al - - 1:695
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Crussell-Porter LL, et al. Arch Intern Med. 1993: 153:102.
Publication : Arch Intern Med by
> Crussell-Porter LL, et al - - 153:102
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Gericke KR. Pharmacotherapy. 1993: 13:508.
Publication : Pharmacotherapy by
> Gericke KR - - 13:508
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Goenen M, et al. J Cardiovasc Surg. 1977: 18:391.
Publication : J Cardiovasc Surg by
> Goenen M, et al - - 18:391
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Lazar JD, et al. Reviews Infect Dis. 1990: 12 (Suppl 3):s327.
Publication : Reviews Infect Dis by
> Lazar JD, et al - - 12 (Suppl 3):s327
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Marotel C, et al. Presse Med. 1986: 15:1684.
Publication : Presse Med by
> Marotel C, et al - - 15:1684
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O'Reilly RA, et al. Clin Pharmacol Ther. 1992: 51:656.
Publication : Clin Pharmacol Ther by
> O'Reilly RA, et al - - 51:656
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Seaton TL, et al. DICP, Ann Pharmacother. 1990: 24:1177.
Publication : DICP, Ann Pharmacother by
> Seaton TL, et al - - 24:1177
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Shenfield GM et al. Aust NZ J Med. 1991: 21:928.
Publication : Aust NZ J Med by
> Shenfield GM et al - - 21:928
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Smith AG. BMJ. 1984: 288:188.
Publication : BMJ by
> Smith AG - - 288:188
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Vanbreuseghem R. Proc Royal Soc Med. 1977: 70 (Suppl 1):51.
Publication : Proc Royal Soc Med by
> Vanbreuseghem R - - 70 (Suppl 1):51
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Watson PG, et al. BMJ. 1982: 285:1045.
Publication : BMJ by
> Watson PG, et al - - 285:1045
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Yeh J. et al. BMJ. 1990: 301:669.
Publication : BMJ by
> Yeh J. et al - - 301:669