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Home : L : Leucovorin Calcium : Leucovorin Calcium and Phenytoin Sodium, Prompt

Effects and Recommendation :
Resulting In: Seizures Folic acid in large amounts may counteract the antiepileptic effect of Phenytoin.
Monitor for increased seizure frequency in susceptible children. Be aware of this potential interaction.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Product Information. Leucovorin Calcium (Leucovorin). Immunex, March 1996.
Publication : Leucovorin Calcium (Leucovorin) by Product Information
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