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Home : O : Olanzapine : Olanzapine and Fluvoxamine Maleate

Effects and Recommendation :
Fluvoxamine Maleate may reduce the clearance and increase the serum levels of Olanzapine.
Monitor for signs of toxicity and lower olanzapine dose if needed.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Callaghan JT, Bergstrom RF, Ptak LR, et al. "Olanzapine. Pharmacokinetic and pharmacodynamic profile." Clin Pharmacokinet. 1999 Sep;37: 177-93.
Publication : Clin Pharmacokinet by
> Callaghan JT, Bergstrom RF, Ptak LR, et al - Olanzapine. Pharmacokinetic and pharmacodynamic pr - 177-93