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Home : Q : Quinidine : Digoxin and Quinidine

Effects and Recommendation :
Resulting In: Digitalis toxicity Quinidine can increase the serum levels of Digoxin and increase the risk of toxicity.
Monitor DIGOXIN level and watch for signs of toxicity. May need to reduce dose of DIGOXIN by 50% when starting QUINIDINE.
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Angelin B, et al. Eur J Clin Invest. 1987: 17:262.
Publication : Eur J Clin Invest by
> Angelin B, et al - - 17:262
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Belz GG, et al. Clin Pharmacol Ther. 1982: 31:548.
Publication : Clin Pharmacol Ther by
> Belz GG, et al - - 31:548
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Bigger JT, et al. Drugs. 1982: 24:229. .
Publication : Drugs by
> Bigger JT, et al - - 24:229.
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Bigger JT, et al. Mod Concepts Cardiovasc Dis. 1982: 51:73. .
Publication : Mod Concepts Cardiovasc Dis by
> Bigger JT, et al - - 51:73.
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Bussey H. Am Heart J. 1982: 104:289. .
Publication : Am Heart J by
> Bussey H - - 104:289.
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Bussey H. Am Heart J. 1984: 107:143. .
Publication : Am Heart J by
> Bussey H - - 107:143.
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Das G, et al. Clin Pharmacol Ther. 1984: 35:317.
Publication : Clin Pharmacol Ther by
> Das G, et al - - 35:317
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Doering W. Eur J Clin Pharmacol. 1983: 25:517.
Publication : Eur J Clin Pharmacol by
> Doering W - - 25:517
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Doering W. N Engl J Med. 1979: 301:400.
Publication : N Engl J Med by
> Doering W - - 301:400
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Fenster PE, et al. Clin Pharmacol Ther. 1984: 36:70.
Publication : Clin Pharmacol Ther by
> Fenster PE, et al - - 36:70
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Fichtl B, et al. Clin Pharmacokinet. 1983: 8:137. .
Publication : Clin Pharmacokinet by
> Fichtl B, et al - - 8:137.
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Hedman A, et al. Clin Pharmacol Ther. 1990: 47:20.
Publication : Clin Pharmacol Ther by
> Hedman A, et al - - 47:20
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Hedman A. Eur J Clin Pharmacol. 1992: 42:457.
Publication : Eur J Clin Pharmacol by
> Hedman A - - 42:457
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Jogestrand T, et al. Eur J Clin Pharmacol. 1984: 27:571.
Publication : Eur J Clin Pharmacol by
> Jogestrand T, et al - - 27:571
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Mordel A, et al. Clin Pharmacol Ther. 1993: 53:457.
Publication : Clin Pharmacol Ther by
> Mordel A, et al - - 53:457
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Pedersen KE, et al. Eur J Clin Pharmacol. 1983: 24:41.
Publication : Eur J Clin Pharmacol by
> Pedersen KE, et al - - 24:41
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Schenck-Gustafsson K, et al. Am J Cardiol. 1983: 51:777.
Publication : Am J Cardiol by
> Schenck-Gustafsson K, et al - - 51:777
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Walker AM, et al. Am Heart J. 1983: 105:1025.
Publication : Am Heart J by
> Walker AM, et al - - 105:1025
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Williams PJ, et al. Clin Pharmacokinet. 1992: 22:66.
Publication : Clin Pharmacokinet by
> Williams PJ, et al - - 22:66