Digoxin and Quinine Sulfate

Effects and Recommendation :
Resulting In: Digitalis toxicity Quinine Sulfate can increase the serum levels of Digoxin and increase the risk of toxicity.
Monitor DIGOXIN level and watch for signs of toxicity. May need a reduction in DIGOXIN dosage.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Aronson JK, et al. Lancet. 1981: 1:1418.
Publication : Lancet by
> Aronson JK, et al - - 1:1418
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Hedman A, et al. Clin Pharmacol Ther. 1990: 47:20.
Publication : Clin Pharmacol Ther by
> Hedman A, et al - - 47:20
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Hedman A. Eur J Clin Pharmacol. 1992: 42:457.
Publication : Eur J Clin Pharmacol by
> Hedman A - - 42:457
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Pedersen KE, et al. Acta Med Scand. 1985: 218:229.
Publication : Acta Med Scand by
> Pedersen KE, et al - - 218:229
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Wandell M, et al. Clin Pharmacol Ther. 1980: 28:425.
Publication : Clin Pharmacol Ther by
> Wandell M, et al - - 28:425

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