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Home : R : Ranitidine : Procainamide HCl and Ranitidine

Effects and Recommendation :
Ranitidine can increase the serum levels of Procainamide HCl and increase the risk of toxicity.
Monitor PROCAINAMIDE level and adjust dosage as needed.
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Martin BK. Br J Clin Pharmacol. 1985: 19:858.
Publication : Br J Clin Pharmacol by
> Martin BK - - 19:858
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Rocci ML, et al. J Pharmacol Exp Ther. 1989: 248:923.
Publication : J Pharmacol Exp Ther by
> Rocci ML, et al - - 248:923
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Rodvold KA, et al. Ther Drug Monit. 1987: 9:378.
Publication : Ther Drug Monit by
> Rodvold KA, et al - - 9:378
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Somogyi A, et al. Br J Clin Pharmacol. 1984: 18:175.
Publication : Br J Clin Pharmacol by
> Somogyi A, et al - - 18:175
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Somogyi A, et al. Br J Clin Pharmacol. 1985: 20:182.
Publication : Br J Clin Pharmacol by
> Somogyi A, et al - - 20:182