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Home : T : Tacrine HCl : Tacrine HCl and Fluvoxamine Maleate
Effects and Recommendation :
Fluvoxamine Maleate may increase the serum levels and pharmacological and adverse effects of Tacrine HCl.
Avoid this combination. Use an alternative such as Fluoxetine; if not, monitor patient for side effects.
Severity of the interaction : 3/6
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Information on this interaction is found in the following publications :
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Becquemont L, Ragueneau I, Le Bot MA, et al. "Influence of CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans." Clin Pharmacol Ther. 1997: 61:619-27.
Publication : Clin Pharmacol Ther by
> Becquemont L, Ragueneau I, Le Bot MA, et al - Influence of CYP1A2 inhibitor fluvoxamine on tacri - 61:619-27
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