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Home : T : Tacrolimus : Tacrolimus and Cyclosporine

Effects and Recommendation :
Resulting In: nephrotoxicity Concomitant administartion of Cyclosporine and Tacrolimus may cause toxicity of both agents.
Avoid this combination. When switching from 1 drug to the other, seperate administration time by at least 24 hours.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Jain AB, et al. Transplant Proc. 1991: 23:2777.
Publication : Transplant Proc by
> Jain AB, et al - - 23:2777
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McCauley J, et al. Transplant Proc. 1990: 22:17.
Publication : Transplant Proc by
> McCauley J, et al - - 22:17