Tacrolimus and Nefazodone HCl

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Home : T : Tacrolimus : Tacrolimus and Nefazodone HCl

Effects and Recommendation :
Resulting In: nephrotoxicity Nefazodone HCl can increase the serum levels of Tacrolimus and increase the risk of toxicity.
Monitor TACROLIMUS level when NEFAZODONE is started or stopped. Adjust TACROLIMUS dosage as needed. Use an alternative to NEFAZODONE such as Paroxetine or Sertraline.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Campo JV, et al. Arch Gen Psychiatry. 1998: 55:1050.
Publication : Arch Gen Psychiatry by
> Campo JV, et al - - 55:1050
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Olyaei AJ, et al. Pharmacotherapy. 1998: 18:1356.
Publication : Pharmacotherapy by
> Olyaei AJ, et al - - 18:1356