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Home : V : Venlafaxine HCl : Tramadol HCl and Venlafaxine HCl
Effects and Recommendation :
Resulting In: Serotonin syndrome Concomitant use of Tramadol and Venlafaxine HCl may cause "serotonin syndrome" including irritability, weakness, tremor, muscle spasm and loss of consciousness.
Monitor patient for adverse effects. Discontinue SEROTONIN agent if interaction occurs. More studies are needed to confirm this interaction.
Severity of the interaction : 5/6
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Information on this interaction is found in the following publications :
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Mackay FJ, Dunn NR, Mann RD. "Antidepressants and the serotonin syndrome in general practice." Br J Gen Pract. 1999 Nov;49: 871-4.
Publication : Br J Gen Pract by Mackay FJ
> Mackay FJ, Dunn NR, Mann RD - Antidepressants and the serotonin syndrome in gene - 871-4
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Ripple MG, Pestaner JP, Levine BS, et al. "Lethal combination of tramadol and multiple drugs affecting serotonin." Am J Forensic Med Pathol. 2000 Dec;21: 370-4.
Publication : Am J Forensic Med Pathol by Ripple MG
> Ripple MG, Pestaner JP, Levine BS, et al - Lethal combination of tramadol and multiple drugs - 370-4
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