| |
Home : V : Venlafaxine HCl : Venlafaxine HCl and Sumatriptan Succinate
Effects and Recommendation :
Resulting In: Serotonin syndrome Concomitant use of Sumatriptan Succinate and Venlafaxine HCl may cause "serotonin syndrome" including irritability, weakness, tremor, muscle spasm and loss of consciousness.
Avoid this combination if possible. Start with low dose and monitor patient closely.
Severity of the interaction : 5/6
|
Information on this interaction is found in the following publications :
----------
Blier P, et al. J Clin Psychopharmacol. 1995: 15:106.
Publication : J Clin Psychopharmacol by
> Blier P, et al - - 15:106
----------
Goldberg MR, et al. "Lack of pharmacokinetic and pharmacodynamic interaction between rizatriptan and paroxetine.." J Clin Pharmacol. 1999: 39:192-9.
Publication : J Clin Pharmacol by
> Goldberg MR, et al - Lack of pharmacokinetic and pharmacodynamic intera - 39:192-9
----------
Joffe RT, et al. Acta Psychiatr Scand. 1997: 95:551.
Publication : Acta Psychiatr Scand by
> Joffe RT, et al - - 95:551
----------
Leung M, et al. Headache. 1995: 35:488.
Publication : Headache by
> Leung M, et al - - 35:488
----------
Mathew NT, et al. "Serotonin syndrome complicating migraine pharmacotherapy (abstract)." Cephalalgia. 1996: 16:323.
Publication : Cephalalgia by
> Mathew NT, et al - Serotonin syndrome complicating migraine pharmacot - 16:323
----------
Szabo CP. J Clin Psychiatry. 1995: 56:37.
Publication : J Clin Psychiatry by
> Szabo CP - - 56:37
----------
Wing YK, et al. "Paroxetine treatment and the prolactin response to sumatriptan." Psychopharmacology. 1996: 124:377-9.
Publication : Psychopharmacology by
> Wing YK, et al - Paroxetine treatment and the prolactin response to - 124:377-9
|
|
|
|
|
