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Home : V : Venlafaxine HCl : Venlafaxine HCl and Trazodone HCl
Effects and Recommendation :
Resulting In: Serotonin syndrome Concomitant use of Trazodone HCl and Venlafaxine HCl may cause "serotonin syndrome" including irritability, weakness, tremor, muscle spasm and loss of consciousness. Venlafaxine HCl may increase the serum levels of Traz
Avoid this combination if possible; if not , start with a low dose of TRAZODONE.
Severity of the interaction : 5/6
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Information on this interaction is found in the following publications :
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Bhatara VS; Magnus RD, Paul KL, Preskorn SH. "Serotonin syndrome induced by venlafaxine and fluoxetine:a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechansim." Ann Pharmacother. 1998 Apr;32: 432-6.
Publication : Ann Pharmacother by
> Bhatara VS; Magnus RD, Paul KL, Preskorn SH - Serotonin syndrome induced by venlafaxine and fluo - 432-6
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Reeves RR, Bullen JA. "Serotonin syndrome produced by paroxetine and low-dose trazodone.." Psychosomatics. 1995: 36:159-60.
Publication : Psychosomatics by
> Reeves RR, Bullen JA - Serotonin syndrome produced by paroxetine and low- - 36:159-60
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