Fluorouracil and Warfarin Sodium

Effects and Recommendation :
Resulting In: increased bleeding tendencies Fluorouracil may increase the anticoagulant effects of Warfarin Sodium.
Carefully monitor anticoagulant factors during and after chemotherapy. Adjust WARFARIN dose as necessary.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Booth BW, et al. N Engl J Med. 1981: 305:170.
Publication : N Engl J Med by
> Booth BW, et al - - 305:170
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Brown MC. Pharmacotherapy. 1997: 17:631.
Publication : Pharmacotherapy by
> Brown MC - - 17:631
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Le AT, et al. Ann Pharmacother. 1997: 31:1006.
Publication : Ann Pharmacother by
> Le AT, et al - - 31:1006
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Scarfe MA, et al. Ann Pharmacother. 1994: 28:464.
Publication : Ann Pharmacother by
> Scarfe MA, et al - - 28:464
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Seifter EJ, et al. Cancer Treat Rep. 1985: 69:244.
Publication : Cancer Treat Rep by
> Seifter EJ, et al - - 69:244
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Tashima CK. South Med J. 1979: 72:633.
Publication : South Med J by
> Tashima CK - - 72:633
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Wajima T, et al. Am J Hematol. 1992: 40:238.
Publication : Am J Hematol by
> Wajima T, et al - - 40:238
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Ward K, et al. Cancer Treat Rep. 1984: 68:817.
Publication : Cancer Treat Rep by
> Ward K, et al - - 68:817

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