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Home : W : Warfarin Sodium : Ofloxacin and Warfarin Sodium

Effects and Recommendation :
Resulting In: increased bleeding tendencies Ofloxacin can increase the anticoagulant effects of Warfarin Sodium.
Monitor anticoagulation factors more frequently especially when adding or discontinuing QUINOLONES. Levofloxacin may be a safer alternative.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Baciewicz AM, et al. Ann Intern Med. 1993: 119:1223.
Publication : Ann Intern Med by
> Baciewicz AM, et al - - 119:1223
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Bianco TM, et al. Pharmacotherapy. 1992: 12:435.
Publication : Pharmacotherapy by
> Bianco TM, et al - - 12:435
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Dugoni-Kramer BM. DICP, Ann Pharmacother. 1991: 25:1397.
Publication : DICP, Ann Pharmacother by
> Dugoni-Kramer BM - - 25:1397
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Efthymiopoulos C, et al. Clin Pharmacokinet. 1997: 33(Suppl 1):39.
Publication : Clin Pharmacokinet by
> Efthymiopoulos C, et al - - 33(Suppl 1):39
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Israel DS, et al. Clin Infect Dis. 1996: 22:251.
Publication : Clin Infect Dis by
> Israel DS, et al - - 22:251
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Jolson HM, et al. Arch Intern Med. 1991: 151:1003.
Publication : Arch Intern Med by
> Jolson HM, et al - - 151:1003
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Kamada AK. DICP, Ann Pharmacother. 1990: 24:27.
Publication : DICP, Ann Pharmacother by
> Kamada AK - - 24:27
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Leor J, et al. Ann Intern Med. 1988: 109:761.
Publication : Ann Intern Med by
> Leor J, et al - - 109:761
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Linville D, et al. Am J Med. 1990: 90:765.
Publication : Am J Med by
> Linville D, et al - - 90:765
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Linville T, et al. Ann Intern Med. 1989: 110:751.
Publication : Ann Intern Med by
> Linville T, et al - - 110:751
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Lioa S, et al. J Clin Pharmacol. 1996: 36:1072.
Publication : J Clin Pharmacol by
> Lioa S, et al - - 36:1072
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Millar E, et al. Clin Pharmacokinet. 1992: 22:102.
Publication : Clin Pharmacokinet by
> Millar E, et al - - 22:102
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Mott FE, et al. Ann Intern Med. 1989: 111:542.
Publication : Ann Intern Med by
> Mott FE, et al - - 111:542
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Renzi R, et al. Am J Emerg Med. 1991: 9:551.
Publication : Am J Emerg Med by
> Renzi R, et al - - 9:551
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Rindone JP, et al. Clin Pharm. 1991: 10:136.
Publication : Clin Pharm by
> Rindone JP, et al - - 10:136
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Rocci ML, et al. J Clin Pharmacol. 1990: 30:728.
Publication : J Clin Pharmacol by
> Rocci ML, et al - - 30:728