Trazodone HCl and Warfarin Sodium

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Home : W : Warfarin Sodium : Trazodone HCl and Warfarin Sodium

Effects and Recommendation :
Trazodone HCl can reduce the anticoagulant effects of Warfarin Sodium.
Monitor anticoagulation factors; may need to increase WARFARIN dose as needed.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Hardy JL, Sirois A. "Reduction of prothrombin and partial thromoboplastin times with trazodone." Can Med Assoc J. 1986 Dec: 135:1372.
Publication : Can Med Assoc J by
> Hardy JL, Sirois A - Reduction of prothrombin and partial thromoboplast - 135:1372