Warfarin Sodium and Amiodarone HCl

Effects and Recommendation :
Amiodarone HCl can increase the anticoagulant effects of Warfarin Sodium.
Reduction in dose of ANTICOAGULANT is usually required (25 to 50% reduction is typical). Monitor anticoagulation factors closely (especially for the first 2 to 4 weeks of combined therapy) and adjust WARFARIN dose as needed. (The interaction can persists
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Hamer A, Peter T, Mandel WJ, et al. "The potentiation of warfarin anticoagulation by amiodarone." Circulation. 1982: 65:1025-9.
Publication : Circulation by
> Hamer A, Peter T, Mandel WJ, et al - The potentiation of warfarin anticoagulation by am - 65:1025-9
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Kerin NZ, Blevins RD, Goldman L, et al. "The incidence, magnitude, and time course of the amiodarone-warfarin interaction." Arch Intern Med. 1988: 148:1779.
Publication : Arch Intern Med by
> Kerin NZ, Blevins RD, Goldman L, et al - The incidence, magnitude, and time course of the a - 148:1779
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Martinowitz U, Rabinovich J, Goldfarb D, et al. "Interaction between warfarin and amiodarone." N Engl J Med. 1981: 304:671-2.
Publication : N Engl J Med by
> Martinowitz U, Rabinovich J, Goldfarb D, et al - Interaction between warfarin and amiodarone - 304:671-2

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