Warfarin Sodium and Mestranol/Norethindrone

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Effects and Recommendation :
Mestranol/Norethindrone may alter the therapeutic effects of Warfarin Sodium.
ORAL CONTRACEPTIVES and high dose estrogens may be thrombogenic in rare occasions. No special precautions necessary. Monitor anticoagulation paremeters as usual.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Mammen EF. Am J Obstet Gynecol. 1982: 142:781.
Publication : Am J Obstet Gynecol by
> Mammen EF - - 142:781
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Monig H, et al. Br J Clin Pharmacol. 1990: 30:115.
Publication : Br J Clin Pharmacol by
> Monig H, et al - - 30:115
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Notelovitz M. Clin Obstet Gynecol. 1985: 28:73 (Review).
Publication : Clin Obstet Gynecol by
> Notelovitz M - - 28:73 (Review)