Warfarin Sodium and Metronidazole

Effects and Recommendation :
Resulting In: hemorrhage Metronidazole can increase the anticoagulant effects of Warfarin Sodium.
Monitor anticoagulation factors and adjust dose of ANTICOAGULANT if necessary.
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Dean RP, et al. DICP. 1980: 14:864.
Publication : DICP by
> Dean RP, et al - - 14:864
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Kazmier FJ. Mayo Clin Proc. 1976: 51:782.
Publication : Mayo Clin Proc by
> Kazmier FJ - - 51:782
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O'Reilly RA. N Engl J Med. 1976: 295:354.
Publication : N Engl J Med by
> O'Reilly RA - - 295:354
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Yacobi A, et al. J Pharmacol Exp Ther. 1984: 231:72.
Publication : J Pharmacol Exp Ther by
> Yacobi A, et al - - 231:72

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