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Home : W : Warfarin Sodium : Warfarin Sodium and Miconazole Nitrate

Effects and Recommendation :
Miconazole Nitrate can increase the anticoagulant effects of Warfarin Sodium.
Monitor anticoagulation factors frequently when adding an AZOLE ANTIFUNGAL to WARFARIN. Adjust dose of ANTICOAGULANT as necessary.
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Brass C, et al. Antimicrob Agents Chemother. 1982: 21:151.
Publication : Antimicrob Agents Chemother by
> Brass C, et al - - 21:151
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Colquhoun MC, et al. Lancet. 1987: 1:695.
Publication : Lancet by
> Colquhoun MC, et al - - 1:695
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Crussell-Porter LL, et al. Arch Intern Med. 1993: 153:102.
Publication : Arch Intern Med by
> Crussell-Porter LL, et al - - 153:102
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Gericke KR. Pharmacotherapy. 1993: 13:508.
Publication : Pharmacotherapy by
> Gericke KR - - 13:508
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Goenen M, et al. J Cardiovasc Surg. 1977: 18:391.
Publication : J Cardiovasc Surg by
> Goenen M, et al - - 18:391
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Lazar JD, et al. Reviews Infect Dis. 1990: 12 (Suppl 3):s327.
Publication : Reviews Infect Dis by
> Lazar JD, et al - - 12 (Suppl 3):s327
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Marotel C, et al. Presse Med. 1986: 15:1684.
Publication : Presse Med by
> Marotel C, et al - - 15:1684
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O'Reilly RA, et al. Clin Pharmacol Ther. 1992: 51:656.
Publication : Clin Pharmacol Ther by
> O'Reilly RA, et al - - 51:656
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Seaton TL, et al. DICP, Ann Pharmacother. 1990: 24:1177.
Publication : DICP, Ann Pharmacother by
> Seaton TL, et al - - 24:1177
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Shenfield GM et al. Aust NZ J Med. 1991: 21:928.
Publication : Aust NZ J Med by
> Shenfield GM et al - - 21:928
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Smith AG. BMJ. 1984: 288:188.
Publication : BMJ by
> Smith AG - - 288:188
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Vanbreuseghem R. Proc Royal Soc Med. 1977: 70 (Suppl 1):51.
Publication : Proc Royal Soc Med by
> Vanbreuseghem R - - 70 (Suppl 1):51
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Watson PG, et al. BMJ. 1982: 285:1045.
Publication : BMJ by
> Watson PG, et al - - 285:1045
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Yeh J. et al. BMJ. 1990: 301:669.
Publication : BMJ by
> Yeh J. et al - - 301:669