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Home : Z : Zidovudine : Zidovudine and Didanosine

Effects and Recommendation :
Didanosine may increase serum levels of Zidovudine (AZT). Zidovudine (AZT) may reduce serum levels of Didanosine.
No special precautions. Monitor response and adjust therapy as needed.
Severity of the interaction : 1/6

Information on this interaction is found in the following publications :
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Barry M, et al. "Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in patients with the acquired immunodeficiency syndrome.." Br J Clin Pharmacol. 1994: 37:421-6.
Publication : Br J Clin Pharmacol by
> Barry M, et al - Pharmacokinetics of zidovudine and dideoxyinosine - 37:421-6