Zidovudine and Ganciclovir

Effects and Recommendation :
Resulting In: Hematological disorders Concurrent use of Ganciclovir and Zidovudine (AZT) may cause life-threatening hematologic toxicity.
Avoid this combination. Consider using an alternative to GANCICLOVIR such as Foscarnet (Foscavir).
Severity of the interaction : 5/6

Information on this interaction is found in the following publications :
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Hochster H, Dieterich D, Bozzette S, et al. "Toxicity of combined ganciclovir and zidovudine for cytomegalovirus disease associated with AIDS. An AIDS Clinical Trials Group Study.." Ann Intern Med. 1990: 113:111-7.
Publication : Ann Intern Med by
> Hochster H, Dieterich D, Bozzette S, et al - Toxicity of combined ganciclovir and zidovudine fo - 113:111-7
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Product Information. Ganciclovir (Cytovene). Roche Labs, September 1999.
Publication : Ganciclovir (Cytovene) by Product Information
> Product Information - -

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