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Home : Z : Zidovudine : Zidovudine and Probenecid
Effects and Recommendation :
Resulting In: Influenza-like syndrome Concomitant use of Probenecid and Zidovudine (AZT) can cause myalgia, malaise, fever and skin rash. Probenecid may increase blood levels of Zidovudine (AZT).
Use with caution. Watch for signs of rash and other symptoms.
Severity of the interaction : 3/6
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Information on this interaction is found in the following publications :
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Duckworth AS, Duckworth GW, et al. "Zidovudine with probenecid." Lancet. 1990: 336:441.
Publication : Lancet by
> Duckworth AS, Duckworth GW, et al - Zidovudine with probenecid - 336:441
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Kornhauser DM, Petty BG, Hendrix CW, et al. "Probenecid and zidovudine metabolism." Lancet. 1989: 2:473-5.
Publication : Lancet by
> Kornhauser DM, Petty BG, Hendrix CW, et al - Probenecid and zidovudine metabolism - 2:473-5
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Petty BG, Kornhauser DM, et al. "Zidovudine and probenecid: a warning." Lancet. 1990: 335:1044-5.
Publication : Lancet by
> Petty BG, Kornhauser DM, et al - Zidovudine and probenecid: a warning - 335:1044-5
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Product Information. Zidovudine (Retrovir). Glaxo Wellcome, May 1998.
Publication : Zidovudine (Retrovir) by Product Information
> Product Information - -
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