Zidovudine and Trimethoprim

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Effects and Recommendation :
Trimethoprim may increase the pharmacological effects of Zidovudine (AZT).
This interaction applies mainly to patients with impaired liver function. Monitor the effects of ZIDOVUDINE and lower its dosage as needed.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Chatton JY, Munafo A, et al. "Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide. (abstract)." Br J Clin Pharmacol. 1992: 34:551-4.
Publication : Br J Clin Pharmacol by
> Chatton JY, Munafo A, et al - Trimethoprim, alone or in combination with sulpham - 34:551-4