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Home : Z : Zileuton : Zonisamide and Zileuton

Effects and Recommendation :
Zileuton can increase the serum levels of Zonisamide and increase the risk of toxicity.
Monitor for signs of toxicity and adjust the dose of ZONISAMIDE as needed.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Nakasa H, Nakamura H, Ono S, et al. "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol. 1998 Apr;54: 177-83.
Publication : Eur J Clin Pharmacol by
> Nakasa H, Nakamura H, Ono S, et al - Prediction of drug-drug interactions of zonisamide - 177-83