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Home : Z : Zinc Oxide : Zinc Oxide and Oxytetracycline

Effects and Recommendation :
Zinc Oxide can reduce the absorption of Oxytetracycline. Zinc Oxide may antagonize or reduce the anti-infective effect of Oxytetracycline.
Avoid taking these 2 drugs together. Separate administration time by at least 3 hours.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Penttila O, Hurme H, Neuvonen PJ, et al. "Effect on zinc sulphate on the absorption of tetracycline and doxycycline in man (abstract)." Eur J Clin Pharmacol. 1975: 9:131-4.
Publication : Eur J Clin Pharmacol by
> Penttila O, Hurme H, Neuvonen PJ, et al - Effect on zinc sulphate on the absorption of tetra - 9:131-4