Zinc Sulfate and Oxytetracycline

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Effects and Recommendation :
Zinc Sulfate can reduce the absorption of Oxytetracycline. Zinc Sulfate may antagonize or reduce the anti-infective effect of Oxytetracycline.
Avoid taking these 2 drugs together. Separate administration time by at least 3 hours.
Severity of the interaction : 3/6

Information on this interaction is found in the following publications :
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Mapp RK, McCarthy TJ et al. "The effect of zinc sulphate and of bicitropeptide on tetracycline absorption (abstract)." S Afr Med J. 1976: 50:1829-30.
Publication : S Afr Med J by
> Mapp RK, McCarthy TJ et al - The effect of zinc sulphate and of bicitropeptide - 50:1829-30